VetApprovedRx is an online store offering a number of pet medications for different health conditions in pets including Diabetes. ProZinc Insulin is one of the products provided by VetApprovedRx to help treat diabetes mellitus in cats. This content will entirely explain you the details of ProZinc Insulin.

ProZinc insulin helps in the reduction of hyperglycemia and its related clinical signs in cats with diabetes mellitus. ProZinc is protamine zinc insulin that is FDA approved for use in diabetic cats. Efficacy and safety studies confirmed that ProZinc is effective in controlling hyperglycemia. It can be used as either an initial treatment for newly diagnosed diabetic cats or as an alternative treatment for poorly regulated diabetic cats. This product is available in U-40 10ml pack.


Cats are also likely to have diabetes and would require proper treatment to relieve or manage the problem. There are several pet medications offered in the market to tackle both types of diabetes namely Diabetes Mellitus and Diabetes insipidus.

What Is The Content In ProZinc Insulin?

One mL of ProZinc Insulin contains the following:

  • Recombinant human insulin 40 International Units IU
  • Protamine sulfate 0.466 mg
  • Zinc oxide 0.088 mg
  • Glycerin 16.00 mg
  • Dibasic sodium phosphate
  • Heptahydrate 3.78 mg
  • Phenol added as additive 2.50 mg
  • Hydrochloric acid 1.63 mg water for injection maximum 1005 mg
  • pH is adjusted with hydrochloric acid and/or sodium hydroxide.

How Is ProZinc Insulin Supplied?

ProZinc insulin is a temperature-sensitive medication. It is supplied as a sterile injectable suspension in 10 mL multi-dose vials. Each mL of ProZinc product contains 40 IU recombinant human insulin. Please note as this product is sensitive towards temperature, it requires a special express shipping. Thus, an additional $24.99 shipping and handling fee as 2nd Day Air charges will be added to the order to accommodate these special shipping needs. For any questions, you can contact VetApprovedRx.

What Are The Dosage And Administration ProZinc Insulin?

Ensure to use U-40 insulin syringe only, syringe other than this will result in incorrect dosing. This product is for subcutaneous injection in cats only.

ProZinc insulin should be mixed by gently rolling the vial before withdrawing each dose from the vial. With the use of U-40 insulin syringe, it should be administered subcutaneously on the back of the neck or on the side of the cat. At the start, the initial recommended ProZinc dose is 0.1 – 0.3 IU insulin per pound of cat body weight and 0.2 – 0.7 IU/kg every 12 hours. The dose should be given parallel with or right after a meal.

Your cat should be re-evaluated by the veterinarian at regular intervals, to adjust the dose depending on both clinical signs and glucose nadirs until adequate glycemic control has been attained. In the successful field study, glycemic control was suggested satisfactory if the glucose nadir from a 9-hour blood glucose curve was between 80 and 150 mg/dL and clinical signs of hyperglycemia such as polyuria, weight loss and polydipsia were improved.

Further modifications in the dosage may be required with changes in the cat’s diet, body weight, or a related medication, or if the cat develops the simultaneous infection, inflammation, neoplasia, or an additional endocrine or other medical disorder.

What Are ProZinc Insulin Contraindications?

ProZinc insulin is contraindicated in cats sensitive to protamine zinc recombinant human insulin. It can also contraindicate with any other ingredients in this product. ProZinc insulin can also contraindicate during the episodes of hypoglycemia.

Are There Any ProZinc Insulin Warnings?

  • ProZinc insulin is for use in cats only.
  • Keep away from the reach of children.
  • Avoid contact with eyes. In case of inadvertent contact, immediately flush eyes with running water for minimum of 15 minutes.
  • Injecting this product accidentally may cause hypoglycemia. In such a case, seek medical attention immediately.
  • Exposure to this product may induce a local or systemic allergic reaction in sensitized individuals.

Is There Any Potential Adverse Reactions?

The hypoglycemia, insulin antagonism/ resistance, rapid insulin metabolism, insulin-induced hyperglycemia Somogyi Effect, and local or systemic reactions are the potential adverse reactions from ProZinc insulin.

Of the above the most common adverse reaction observed is hypoglycemia. Its indicating signs are: weakness, changes in behavior, muscle twitching, depression, and anxiety. In severe hypoglycemia cases, seizures and coma can occur. Hypoglycemia can be fatal in an affected cat if a prompt treatment is not received.

The risk of hypoglycemic episodes can be minimized by appropriate veterinary monitoring of blood glucose, modification of insulin dose and routine as needed, and stabilization of activity and diet. The attending veterinarian should evaluate other adverse reactions as well on a case by case basis to determine if an alteration in therapy is required, or if alternative therapy should be considered.

What Are ProZinc Insulin Precautions?

Animals with severe ketoacidosis, lethargy, anorexia, and/or vomiting should be stabilized with short-acting insulin. An appropriate supportive therapy should be given until their condition is stabilized. As with all insulin products including ProZinc insulin, cautious patient monitoring for hypoglycemia and hyperglycemia are essential to attain and maintain adequate glycemic control and to prevent related complications.

Overdosage can result in profound hypoglycemia and death of the cat. Progestogens, certain endocrinopathies, and glucocorticoids can have an antagonistic effect on insulin activity. Thus, avoid using Progestogen and glucocorticoid.

What Are The Reproductive Safety Measures?

  • The safety and effectiveness of ProZinc insulin in pregnant, breeding and lactating cats has not been evaluated.
  • The safety and effectiveness of this product in kittens has also not been evaluated.

What Are The Proper Storage Conditions?

  • Store this product in an upright position under refrigeration at 36-46°F or 2-8°C only.
  • Do not freeze the product.
  • Protect ProZinc insulin from light.

To buy ProZinc insulin, a veterinarian prescription is required. You will have to provide your veterinarian Fax number or email address during check out. VetApprovedRx will then send him or her prescription confirmation which your veterinarian will sign and return so that the product can be ship to you.